http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009528310-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 2007-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009528310-A |
| titleOfInvention | Method for obtaining enantiomers of duloxetine precursor |
| abstract | The present invention relates to a process for preparing an enantiomerically enriched compound of II, or a pharmaceutically acceptable salt, complex or solvate thereof, in the presence of a chiral ligand. A method of preparation comprising an enantioselective addition reaction with a zinc reagent: Where R 1 , R 2 and R 3 are each independently selected from hydrogen, halogen, substituted or unsubstituted lower alkyl or substituted or unsubstituted aryl; X is —C (═O) —Z or —Y, wherein —Y is selected from —CH 2 —OR 4 , —CH 2 —halogen or —CH 2 —NR 6 R 7 ; Where Z is selected from —NR 6 R 7 or —OR 5 where R 5 is selected from hydrogen, substituted or unsubstituted lower alkyl or ester activating group; R 4 is selected from hydrogen, hydroxyl protecting group or hydroxy activating group; R 6 and R 7 are each independently selected from hydrogen, amino protecting group, amide protecting group or substituted or unsubstituted lower alkyl. [Selection figure] None |
| priorityDate | 2006-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.