| abstract |
The present disclosure relates to agents and methods that modulate the function of CD200. Agents that modulate the function of CD200 include agents that modulate the activity and / or expression of CD200 and / or its receptor (CD200R). In some embodiments, the agent inhibits CD200 function or activity. Thus, in certain aspects, the agent acts as an antagonist to CD200. Certain antagonists can bind to CD200 and inhibit or prevent the interaction between CD200 and its receptor. Other antagonists bind to CD200 but cannot interfere with the CD200: CD200R interaction. Thus, a CD200 antagonist includes any agent that can modulate the effects of CD200 by a mechanism that includes or does not include a block of the CD200: CD200R interaction. |