| abstract |
The present invention relates to novel chromen-2-one derivatives of formula (I) useful as inhibitors of monoamine neurotransmitter reuptake. In another aspect, the invention relates to the use of these compounds in a method of treatment and to pharmaceutical compositions comprising the compounds of the invention. In formula (I), Q represents a chromen-2-one group, which is halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy , Alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl, optionally substituted with one or more substituents independently selected from the group consisting of R 1 represents hydrogen or alkyl, One or more independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl Optionally substituted with a substituent, R 2 and R 3 together form — (CH 2 ) — (CH 2 ) — or — (CH) ═ (CH) —. |