| abstract |
The present invention relates to compounds useful as protein kinases, particularly JAK family kinase inhibitors. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. These compounds, and pharmacologically acceptable compositions thereof, include proliferative diseases, heart diseases, neurodegenerative diseases, autoimmune diseases, symptoms related to organ transplantation, inflammatory diseases, or immune-mediated diseases Useful in treating various diseases in patients or reducing their severity. The compounds and compositions provided by the present invention are also used in studies of JAK kinases in biological and pathological phenomena, studies of intracellular signaling pathways mediated by the kinases, and comparative evaluation against novel kinase inhibitors. Is also useful. |