| abstract |
Provided are engineered that bind antigen with high affinity, have high immunogenicity, exhibit MHC class I priming, and can be produced in non-mammalian cells such as E. coli A fusion polypeptide comprising an antibody and a stress protein. An isolated nucleic acid encoding the fusion polypeptide, an expression vector comprising the nucleic acid, a cell comprising the expression vector, a pharmaceutical composition comprising the fusion polypeptide and a pharmaceutically acceptable carrier, the fusion polypeptide Also provided are immunogenic compositions or vaccines comprising, kits comprising such compositions, and the like. |