| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-034 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-461
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate |
2007-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2009-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2009525042-A |
| titleOfInvention |
Method for producing water-soluble recombinant protein in original form with signal sequence and secretion enhancer |
| abstract |
The present invention uses a secretion enhancer composed of a modified signal sequence comprising a signal sequence N-region and / or a hydrophobic fragment of said signal sequence comprising said N-region and / or hydrophilic polypeptide, The present invention relates to a method for improving the secretion efficiency of foreign proteins. The method of the present invention can be used for the production of recombinant foreign proteins by preventing insoluble precipitation and increasing the secretion efficiency of the recombinant protein into the periplasm or extracellular fluid, and also uses a strong secretion enhancer Thus, by increasing the membrane permeability of the recombinant protein, it can be used for the transmission of proteins for therapeutic purposes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019064972-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019516371-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014513956-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-6994714-B2 |
| priorityDate |
2006-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |