| abstract |
The present invention relates to depression, anxiety disorder, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress related disorders, psychotic disorders (eg schizophrenia), neurological diseases (eg Parkinson's disease), neurodegeneration Disorders (eg Alzheimer's disease), epilepsy, migraines, hypertension, drug abuse, and metabolic disorders (eg eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, energy expenditure and assimilation disorders), Formula I, wherein R is hydrogen, hydroxy, lower alkyl, lower, for the manufacture of a medicament for the treatment of disorders of body temperature homeostasis and disorders, sleep and circadian rhythm disorders, and cardiovascular disorders alkoxy, halogen, or lower alkyl substituted by halogen, or 4- (CH 2) 2 C ( O) - naphthyl; X is -S- or -NH- Aryl is an aromatic group selected from phenyl, naphthalen-1-yl, naphthalen-2-yl or 5,6,7,8-tetrahydronaphthalen-1-yl; hetaryl is at least one N Or an aromatic group containing an S ring atom and selected from the group consisting of thiophen-3-yl or pyrimidin-5-yl; n is 1, 2 or 3], and pharmaceuticals thereof To the use of chemically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms. |