| abstract |
The present invention relates to a 5-membered azacyclo compound of formula (I), pharmaceutically acceptable salts thereof and hydrates thereof, wherein the groups are as defined in the specification. The present invention further includes a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof or a hydrate thereof, and (i) improvement of skin elasticity or reduction of skin wrinkles of the pharmaceutical composition. , (Ii) treatment of diabetes, (iii) treatment or reduction of adverse sequelae of diabetes, (iv) treatment or reduction of kidney damage, (v) treatment or reduction of damage to blood vessels, (vi) treatment of hypertension Or (vii) treatment or reduction of retinopathy, (viii) treatment or reduction of lens protein disorders, (ix) treatment or reduction of cataracts, (X) treatment or reduction of peripheral neuropathy, or (xi) deformation It relates to use in the treatment or alleviation of osteoarthritis. The invention further relates to the use in the manufacture of oral formulations for preventing or reversing dental stains, or in the manufacture of crop plant or animal protein freshness-preserving agents. [Chemical 1] [Selection figure] None |