| abstract |
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is mediated by MMP, ADAM, TACE, aggrecanase, TNF-α or combinations thereof. Useful for the treatment of the disease or condition. Inhibition of TNF-α, TACE and / or other MMPs can prevent cartilage degradation by these enzymes, thereby alleviating OA and RA pathological conditions, as well as many other autoimmune diseases. |