| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate |
2007-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2009-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2009523726-A |
| titleOfInvention |
Hydroxyalkyl arylamide derivatives |
| abstract |
The present invention relates to a new class of hydroxyalkylarylamide derivatives. The compounds of the present invention can be used to treat cancer. This fluorinated arylamide derivative can also inhibit histone deacetylase and selectively induce terminal differentiation of neoplastic cells and cell growth arrest and / or apoptosis, thereby Suitable for use in inhibiting the growth of Thus, the compounds of the present invention are useful for treating patients with tumors characterized by neoplastic cell proliferation. The compounds of the present invention are also used in the prevention and treatment of TRX-mediated diseases such as autoimmune, allergic and inflammatory diseases and in the prevention and / or treatment of central nervous system (CNS) diseases such as neurodegenerative diseases. Or it may be useful in therapy. The present invention further provides pharmaceutical compositions comprising hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions that are easy to follow and produce a therapeutically effective amount of the hydroxamic acid derivative in vivo. A dosing regimen is also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9914717-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793538-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9790184-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9365498-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10662199-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9447030-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014523857-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11377423-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11572368-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9890172-B2 |
| priorityDate |
2006-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |