| abstract |
The present invention relates to S1P1 / EDG1 receptor agonists of formula (I) and their use as active ingredients in the manufacture of pharmaceutical compositions. The present invention also relates to a process for the preparation of said compounds, pharmaceutical compositions comprising a compound of formula (I), as well as compounds that improve vascular function and as immunomodulators, alone or in other active compounds Or related aspects, including their use in combination with therapy. A further aspect of the invention relates to novel compounds of formula (II) and (III) which serve as intermediates for the preparation of compounds of formula (I). [Selection figure] None |