| abstract |
The present invention provides methods, nucleic acids, compositions and methods for predicting a subject's response to treatment with activated protein C or a protein C-like compound to determine subjects who will benefit more from treatment with activated protein C. Provide kit. In general, the method comprises the step of determining the genotype of the protein C pathway-related gene polymorphism in the subject for one or more polymorphisms in the protein C pathway-related gene, and determining the determined genotype. Compared to known genotypes and polymorphisms that correspond to response-enhancing polymorphisms and more likely to benefit from treatment with activated protein C or protein C-like compounds and subsequent recovery of inflammatory symptoms Determining a target person. The invention also provides a method of treating such a subject with an anti-inflammatory or anticoagulant based on the subject's genotype. |