| abstract |
The present invention provides compositions and methods that facilitate the identification of compounds that can interact with a subject biopolymer. In one aspect, a composition comprising an array of one or more types of compounds attached to a solid support using isocyanate or isothiocyanate chemistry is provided, wherein the density of the array of compounds is at least 1000 spots per cm 2 . In general, these inventive arrays include: (1) providing a solid support functionalized with an isocyanate or isothiocyanate moiety capable of interacting with a desired compound to form a covalent bond; (2) Providing one or more solutions of one or more types of compounds to be bound to the solid support; (3) delivering one or more types of compounds to the solid support; and (4) solids of the compounds. And catalyzing the binding to the support, thereby forming an array, the array of compounds having a density of at least 1000 spots per cm 2 . |