| abstract |
Amino acid derivatives of pyrrolylindolinone and their amide or ester derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in the treatment of disorders related to abnormal protein kinase activity such as cancer. The compounds of the present invention can control and / or modulate the protein kinase activity of VEGFR and / or PDGFR. Furthermore, the present invention provides a means for treating disorders related to abnormal function of these kinases. Such disorders include glioblastoma, melanoma and Kaposi's sarcoma and solid tumors such as ovary, lung, prostate, pancreas, colon and epidermoid carcinoma. |