| abstract |
The present invention provides a compound having excellent JAK3 inhibitory activity and useful as an active ingredient of a therapeutic and / or prophylactic agent for various immune diseases including autoimmune diseases, inflammatory diseases and allergic diseases. Since the compounds of the present invention have inhibitory activity against JAK3, diseases caused by unwanted cytokine signaling (eg, rejection in living transplants, autoimmune diseases, multiple sclerosis, rheumatism, psoriasis, asthma, atopy) Dermatitis, Alzheimer's disease, atherosclerosis), or a disease caused by abnormal cytokine signaling (eg, cancer, leukemia), it has been confirmed to be useful as an active ingredient of a therapeutic or prophylactic agent. |