http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009521516-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 |
| filingDate | 2006-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009521516-A |
| titleOfInvention | Aryl-isoxazol-4-yl-imidazole derivatives |
| abstract | The present invention is directed to formula I wherein R 1 to R 3 are each independently hydrogen or halogen; R 4 is hydrogen, lower alkyl, cycloalkyl, — (CH 2 ) n —O-lower alkyl Or lower alkyl substituted with hydroxy; R 5 is — (CH 2 ) m -aryl or — (CH 2 ) m -heteroaryl, which is optionally halogen, cyano, nitro, Lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkyl substituted with halogen, -C (O) -lower alkyl, -C (O) -O-lower alkyl, -NH-C (O) -O-lower Substituted with one or more substituents selected from the group consisting of alkyl or —C (O) —NH—R ′, wherein R ′ is substituted with lower alkynyl or halogen. Lower alkyl or optionally substituted with halogen, - (CH 2) n - cycloalkyl, - (CH 2) n - heterocyclyl, - (CH 2) n - heteroaryl or - (CH 2) n - aryl; R 6 is hydrogen; -C (O) H ;-( CH 2) n -O- lower alkyl; -C (O) O-lower alkyl; lower substituted with hydroxy or halogen alkyl, or cycloalkyl, aryl, or substituted by halogen or lower alkyl by, - (CH 2) n -O -CH 2 - halogen or aryl, or lower Is — (CH 2 ) n —O—CH 2 -heteroaryl substituted with alkyl or lower alkyl substituted with halogen? Or — (CH 2 ) n —NH— (CH 2 ) o -heterocyclyl; n is 0, 1, 2, or 3; m is 0 or 1; o is 1, 2 or 3}, and pharmaceutically acceptable acid addition salts thereof. This class of compounds has been found to exhibit high affinity and selectivity for the GABA A α5 receptor binding site and is useful as a nootropic or for the treatment of cognitive disorders such as Alzheimer's disease. ing. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015528486-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014502279-A |
| priorityDate | 2005-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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