| abstract |
The present invention is represented by formulas (I)-(IX), which may be useful for the treatment of diseases or conditions mediated by MMP, aggrecanase, ADMP, LpxC, ADAM, TACE, TNF-α or combinations thereof. It relates to compounds, or pharmaceutically acceptable salts, solvates, esters or isomers thereof. Diseases that can be treated by the compounds of the present invention include rheumatoid arthritis, osteoarthritis, periodontitis, gingivitis, corneal ulcer, solid tumor growth and tumor invasion by secondary metastasis, neovascular glaucoma, inflammatory bowel disease, multiple Examples include sclerosis and psoriasis. |