| abstract |
The present invention provides a stable metastin derivative having excellent biological activity (cancer metastasis inhibitory activity, cancer growth inhibitory activity, gonadotropin secretion promoting activity, sex hormone secretion promoting activity, etc.). The metastin derivative of the present invention can be further improved in blood stability and solubility, reduced gelation tendency, improved pharmacokinetics, and excellent cancer by substituting specific amino acids for metastin constituent amino acids. It exhibits metastasis inhibitory activity and cancer growth inhibitory activity. Furthermore, the metastin derivative of the present invention has a gonadotropin secretion inhibitory action, a sex hormone secretion inhibitory action and the like. [Selection figure] None |