abstract |
The aromatic heterocyclic compound represented by the structural formula (I) is a selective inhibitor of stearoyl-coenzyme Aδ-9 desaturase (SCD1) as compared with other known stearoyl-coenzyme A desaturases. The compounds of the present invention can be used in abnormal lipid synthesis and metabolism including cardiovascular diseases such as atherosclerosis; lipid disorders, obesity, diabetes, neurological diseases; metabolic syndrome; insulin resistance, fatty liver disorders and cancer. Useful for the prevention and treatment of related medical conditions. [Chemical 1] |