| abstract |
The present invention relates to the formula P-L-N, where P is a cell penetrating peptide, N is a nucleic acid, preferably an oligonucleotide, more preferably siRNA, and L is a hydrophilic polymer linking P and N. Cell-penetrating peptide-nucleic acid ("CPP-nucleic acid") conjugates, preferably polyethylene glycol (PEG) based linkers, are provided. Compositions, methods of use, and methods of making such conjugates are also disclosed. |