abstract |
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells, and methods for expressing the antibodies of the invention are also provided. Also provided are pharmaceutical compositions comprising an immunoconjugate, a bispecific molecule, and an antibody of the invention. The present invention further provides a method for treating various diseases including cancer and infectious diseases in addition to a method for detecting PTK7 using an anti-PTK7 antibody. |