abstract |
The present invention relates to a composition for diagnosing cancer metastasis comprising ubiquitin C-terminal hydrolase-L1 (UCH-L1), the use of UCH-L1 for diagnosing cancer metastasis, a method for diagnosing cancer metastasis using UCH-L1, UCH-L1 A composition for suppressing cancer metastasis comprising an inhibitor of cancer, a screening composition for cancer metastasis inhibitor comprising UCH-L1, use of UCH-L1 for screening for cancer metastasis inhibitor, cancer metastasis using UCH-L1 Inhibitor screening methods. UCH-L1 is a key molecule that modulates cell migration including cancer invasion according to the expression level. Thus, monoclonal and polyclonal antibodies and UCH-L1 substrates can be used for diagnosis of cancer metastasis. Cancer metastasis can be suppressed by inhibiting the expression of UCH-L1 or the activity of its enzyme. Therefore, we can screen and develop inhibitors of UCH-L1 and use them as adjuvants for anticancer treatment. |