| abstract |
The present invention relates to live attenuated S. Paratyphi A strains, live attenuated S. Paratyphi A strains containing a stabilized plasmid expression system and methods of using these strains. In one embodiment, the S. Paratyphi A strain of the present invention has at least one attenuating mutation selected from the group consisting of attenuating mutations in the guaBA locus, the guaB gene, the guaA gene, the clpP gene and the clpX gene. Have. In a preferred embodiment, the S. Paratyphi A strain has an attenuating mutation in the guaB gene, the guaA gene and the clpP gene. |