| abstract |
The present invention relates to compounds of the following formula useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions for the treatment of various disorders. These compounds and their pharmaceutically acceptable compositions include, but are not limited to, acute, chronic, neuropathic or inflammatory pain, arthritis, migraine, cluster headache, trigeminal neuralgia, herpes neuralgia, systemic neuralgia, Epilepsy or epilepsy state, neurodegenerative disorders, mental disorders such as anxiety and depression, myotony, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, degenerative joints Includes pain, postherpetic neuralgia, diabetic neuropathy, root pain, sciatica, back pain, head or neck pain, severe or refractory pain, nociceptive pain, breakthrough pain, postoperative pain, or cancer pain Useful for treating or alleviating various diseases, disorders, or symptoms. |