| abstract |
Painful by locally or locally delivering compounds that interact with α2 adrenergic receptors, particularly α2 adrenergic agonists such as clonidine, to the entire painful area so that the need for systemic administration is minimized Compositions for the treatment of sexual neuropathy and methods of use thereof are provided. The compounds are delivered to or adjacent to the painful area of patients with painful length-dependent neuropathy and other neuropathies that affect cutaneous pain signaling fibers. Preferred compounds for the treatment of patients with length-dependent neuropathy are clonidine administered in transdermal patches, gels, ointments, lotions, liposomal formulations, creams or emulsions, in which case the concentration is painful It is sufficient to provide an effective dose to a region or a region immediately adjacent thereto. |