| abstract |
The present invention relates to a new class of substituted nicotinamides. These compounds can inhibit histone deacetylase and selectively induce terminal differentiation, cell growth arrest and / or apoptosis of neoplastic cells, thereby inhibiting the growth of such cells It is suitable for use in Accordingly, the compounds of the present invention are useful in treating patients with tumors characterized by neoplastic cell proliferation. The compounds of the present invention are also used in the prevention and treatment of TRX-mediated diseases, such as autoimmune diseases, allergic diseases, and inflammatory diseases, and in the central nervous system (CNS) diseases such as neurodegenerative diseases. It may also be useful in prevention and / or treatment. The present invention further includes pharmaceutical compositions comprising the compounds of the present invention and the safety of these pharmaceutical compositions that are easy to follow and result in a therapeutically effective amount of these compounds in vivo. Provide a dosing regimen. |