| abstract |
The present invention relates to the fields of vaccination, immunology and medicine. The present invention relates to an immunostimulatory nucleic acid, preferably an antigen bound or fused to a virus-like particle (VLP) packaged with an oligonucleotide containing at least one unmethylated CpG sequence and a toll-like receptor (TLR) ligand. Compositions and methods for enhancing an immunological response are provided. The present invention can be used to elicit strong antibodies and T cell responses that are particularly effective in the treatment of allergies, tumors and chronic viral diseases and other chronic diseases. |