| abstract |
This application has the general structure shown in formula (1) and has various moieties as defined herein, or the enantiomers, stereoisomers, rotamers, tautomers of said compounds. Body, racemate or prodrug, or pharmaceutically acceptable salt, solvate or ester of said compound or said prodrug. Also, methods for treating chemokine-mediated diseases, for example, inflammatory diseases (including, but not limited to, psoriasis), autoimmune diseases (including, but not limited to, rheumatoid arthritis, multiple disease) using the compound of formula (1) Sclerosis), graft rejection (non-limiting examples include allograft rejection, xenograft rejection), infection (eg tuberculosis), fixed drug eruption, skin delayed hypersensitivity reaction Also disclosed are palliative treatments, curative therapies, and preventive therapies for certain diseases and conditions such as type 1 diabetes, viral meningitis and tumors. |