| abstract |
Vectors and methods for producing influenza viruses suitable as recombinant influenza vaccines by cell culture are provided. Bidirectional expression vectors for use in multi-plasmid influenza virus expression systems are provided. Furthermore, the present invention provides a method for producing an influenza virus with enhanced ability to replicate in growing chicken eggs and / or cells (eg, Vero and / or MDCK), and further provides an influenza virus with enhanced replication characteristics To do. [Selection figure] None |