| abstract |
The present invention relates to novel agents useful for controlling sumoylation. In particular, the invention provides: (i) a pharmaceutically effective amount of an HLS-5 polypeptide, an isoform thereof, a functional fragment thereof, or a pharmaceutical composition thereof; or (ii) an endogenous form of HLS-5 or an activity thereof. Or (iii) a combination thereof, or a sumoylation control agent comprising: |