| abstract |
A poxvirus protein called A41L and 130L binds to three receptor-like protein tyrosine phosphatases (RPTP) present on the cell surface of immune cells, namely leukocyte common antigen-related protein (LAR), RPTP-δ and RPTP-σ To do. When the host is infected with a poxvirus, A41L binds to the cell surface protein of the host cell and suppresses the immune response. The present invention relates to antibodies and antigen-binding fragments thereof, which interact with one or more of LAR, RPTP-δ and RPTP-σ expressed by immune cells, or interact with a polynucleotide encoding RPTP, Agents such as molecules, aptamers, short interfering RNA and peptide-IgFc fusion polypeptides are provided. Such agents are useful for treating an immune disorder in a subject according to the methods described herein. [Selection] Figure 3 |