| abstract |
Contemplated compositions and methods include combinations of tea polyphenol compositions and lactoferrin to prevent and / or treat oral cancer with significantly higher efficiency than treatment with either tea polyphenol compositions or lactoferrin alone. It is effective. Such improved efficiency is also reflected in various clinical and systemic parameters, which are regulated activity of phase 1 / phase 2 enzymes, cytokeratin, NF-κB, Bcl− 2, including expression of PCNA, and alteration of cell proliferation and induction of apoptosis. |