| abstract |
The present invention relates to methods of treating protein degradation disorders, such as cell proliferation disorders (eg, cancer) and protein degradation disorders (eg, neurodegenerative disorders). The present invention provides methods and pharmaceutical compositions for treating these diseases using an aggresome inhibitor, or a combination of an aggresome inhibitor and a proteasome inhibitor. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC / TDAC inhibitors and aggresome inhibitors and synthetic methods for synthesizing these compounds are also provided. |