| abstract |
The present invention provides formulations, kits, and methods useful for treating cell proliferative disorders. In particular, the formulations, kits, and methods include temozolomide (TMZ) in combination with a protein kinase C (PKC) inhibitor. In one embodiment, the present invention provides formulations, kits, and methods comprising TMZ or a pharmaceutically acceptable salt thereof in combination with a PKC inhibitor. In another embodiment, the present invention provides formulations, kits, and methods comprising TMZ or a pharmaceutically acceptable salt thereof in combination with a selective PKC beta inhibitor. |