| abstract |
The present invention provides topical compositions comprising O-desmethylvenlafaxine (ODV), or a pharmaceutically acceptable salt thereof, which is a selective serotonin and norepinephrine reuptake inhibitor. In certain embodiments, the topical formulations of the present invention include one or more transdermal / transmucosal absorption enhancers. Also provided are methods of preparing and using these compositions for the treatment of various diseases or conditions such as vasomotor signs and pain. |