| abstract |
The present invention provides a stable pharmaceutical composition of a poorly water-soluble pharmaceutical agent and a stabilizer having a function of enhancing the stability of the composition. The use of stabilizers can increase the stability of nanoparticulate suspensions of poorly water-soluble drugs such as docetaxel and other formulations, for example, under predetermined conditions such as dilution for administration. Accordingly, in one aspect, the present invention is a composition (eg, pharmaceutical composition) comprising a poorly water soluble pharmaceutical (eg, docetaxel) and a stabilizer, compared to a composition without the stabilizer. In some cases, compositions are provided that have enhanced stability. |