| abstract |
The present invention provides triazole macrocycles useful as therapeutic agents. More specifically, these compounds are useful as anti-infective agents, anti-proliferative agents, anti-inflammatory agents and prokinetic agents. These compounds are represented by the following formula (I), wherein R 1 , R 2 and the like are as defined in claim 1. The present invention provides compounds useful as antiinfectives and / or antiproliferative agents, for example, as antibiotic agents, antibacterial agents, antimicrobial agents, antifungal agents, antiparasitic agents, antiviral agents and chemotherapeutic agents To do. The present invention further provides compounds useful as anti-inflammatory agents and / or motility promoting (gastrointestinal modulating) agents. The invention further provides these pharmaceutically acceptable salts, esters, N-oxides or prodrugs. |