| abstract |
The present invention is a novel triazole derivative as a ghrelin analog ligand of the growth hormone secretagogue receptor of formula (I), which is physiologically mediated in mammals, preferably humans, mediated by the GHS receptor. And / or triazole derivatives useful in the treatment or prevention of pathophysiological conditions. Furthermore, the present invention provides GHS receptor antagonists and agonists that can be used for the modulation of these receptors, which are suitable for the aforementioned conditions, especially “growth retardation, cachexia, short periods of energy balance, medium Long-term and / or long-term regulation; short-, medium- and / or long-term regulation of eating behavior (stimulation and / or inhibition); adipogenesis, adiposity and / or obesity; weight gain and / or decline Useful for treating "diabetes, type 1 diabetes, type 2 diabetes, tumor cell proliferation; inflammation, inflammatory effects, postoperative ileus of the stomach, postoperative ileus and / or gastrectomy (ghrelin replacement therapy)". |