| abstract |
The present invention relates to novel substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of derivatives comprising a pharmaceutically acceptable carrier, and uses of the compounds. In one aspect, the present invention provides a method of treating a mammalian patient suffering from a disorder mediated at least in part by KSP. Accordingly, the present invention provides a method of treating a mammalian patient in need of such treatment comprising administering to the patient a therapeutically effective amount of a substituted imidazole compound, alone or in combination with other anticancer agents. The compounds of the present invention have the following general formula: Have |