| abstract |
The properties of Fc-containing proteins such as antibodies are controlled by altering sialylation of oligosaccharides in the Fc region. Modified Fc-containing proteins are in diseases or conditions where it is desirable to control affinity for one or more of FcgRI, FcgRIIA and FcgRIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life and avidity Has therapeutic utility. |