| abstract |
Cytotoxic conjugates comprising cell binding agents and cytotoxic agents, therapeutic compositions comprising the conjugates, methods for using the conjugates in inhibiting cell proliferation and treating diseases, and the cytotoxic conjugates Disclosed are kits comprising gates, all of which are aspects of the present invention. In particular, cell binding agents are monoclonal antibodies and epitope binding fragments thereof that recognize and bind to the CA6 glycotope. The invention also relates to humanized or resurfaced forms of DS6, anti-CA6 murine monoclonal antibodies, and epitope-binding fragments thereof. |