| abstract |
The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and / or SMC proliferation in mammals. The disclosed compounds are useful for modulating markers of inflammatory conditions, including vascular inflammation, and for the treatment and prevention of inflammatory and cardiovascular diseases and related disease states. One embodiment provides methods and compositions that are useful for inhibiting VCAM-1 expression, MCP-1 expression and / or SMC proliferation in a mammal. In certain embodiments, the methods and compositions of the present invention treat inflammatory conditions and associated disease states characterized by altered expression of markers of inflammation such as VCAM-1, MCP-1 and / or SMC proliferation. Useful for treating, preventing or alleviating. |