http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009502885-A
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D245-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D225-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D245-04 |
filingDate | 2006-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2009-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2009502885-A |
titleOfInvention | Macrocyclic inhibitor of hepatitis C virus |
abstract | Formula (I) [Chemical 1] Wherein each dotted line (represented by -----) represents a double bond that may optionally be present; X is N, CH, and if X possesses a double bond it is R 1 is —OR 6 , —NH—SO 2 R 7 ; when R 2 is hydrogen, and X is C or CH, R 2 is also C 1-6 alkyl Can be; R 3 is hydrogen, C 1-6 alkyl, C 1-6 alkoxy C 1-6 alkyl or C 3-7 cycloalkyl; n is 3, 4, 5 or 6; R 4 And R 5 are independently of each other hydrogen, halo, hydroxy, nitro, cyano, carboxyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy C 1-6 alkyl, C 1-6 alkylcarbonyl , C 1-6 alkoxycarbonyl, amino, Azide, mercapto, C 1-6 alkylthio, polyhaloC 1-6 alkyl, aryl or Het; W is aryl or Het; R 6 is hydrogen; aryl; Het; optionally substituted with C 1-6 alkyl Optionally C 3-7 cycloalkyl; or optionally C 3-7 cycloalkyl, C 1-6 alkyl optionally substituted with aryl or Het; R 7 is aryl; Het; optionally C C 3-7 cycloalkyl optionally substituted with 1-6 alkyl; or optionally C 3-7 cycloalkyl, C 1-6 alkyl optionally substituted with aryl or Het; each aryl is Optionally substituted with 1 to 3 substituents, phenyl or naphthyl; Het is N A 5- or 6-membered saturated, partially unsubstituted group containing 1 to 4 heteroatoms, each independently selected from O or S, and optionally substituted with 1 to 3 substituents. Saturated or fully unsaturated heterocycle] Inhibitors of HCV replication and N-oxides, salts or stereoisomers thereof; pharmaceutical compositions containing compound (I) and methods for preparing compound (I). A bioavailable combination of ritonavir with an inhibitor of HCV of formula (I) is also provided. |
priorityDate | 2005-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 714.