http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009502858-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65068 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6506 |
| filingDate | 2006-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2009502858-A |
| titleOfInvention | Novel benzimidazole (thio) carbamate with antiparasitic activity and its synthesis |
| abstract | The present invention relates to a novel benzimidazole (thio) carbamate having antiparasitic activity. The present invention relates to the following general formula (I) Wherein X 1 and X 2 are O or S, at least one of X 1 and X 2 is O, Y 1 and Y 2 are O or S, and Y 1 and Y 2 At least one is O and R 1 is alkyl of 1 to 4 carbon atoms, R 2 , R 3 and R 4 are independently of each other hydrogen or cation, and R 5 and R 6 are independently of each other Is hydrogen or halogen or alkyl having 1 to 8 carbon atoms, or -OR 7 where R 7 is alkyl having 1 to 8 carbon atoms, or alkyl having 8 to 8 carbon atoms, or aryl. —SR 8 , or R 9 is alkyl having 1 to 8 carbon atoms, or cycloalkyl having 3 to 6 carbon atoms, or —CO—R 9 where R 9 is aryl, or Ar is aryl. In -OSO 2 -Ar, or R 10 is alkyl having 1 to 8 carbon atoms, or R 10 is aryl (-S (O) R 10 ). The compounds of the present invention are highly soluble in water and stable in water. Furthermore, it has been found that the compounds according to the invention are stable over 8 hours, at pH 5 and pH 9, the lower and upper pH where the compound should be stable over 8 hours in order to be suitable for drinking water administration. The compounds of the present invention have excellent anthelmintic activity, especially in vivo anthelmintic activity, comparable to the latest water-insoluble benzimidazole carbamates such as albendazole and fenbendazole. |
| priorityDate | 2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.