| abstract |
The present invention relates to analogues of 6-thioguanosine triphosphate of general formula (I). In the compound of the general formula (I), the broken bond in the sugar component is a single or double bond, and R1, R2, R3, R4 or R5 are the same or different from each other, and the general formula-(Int) m- Ter, m is 0 to 12, Int and Ter are internal and terminal building blocks, Int is selected from the group consisting of formula (II); Ter is formula (III) Selected from the group consisting of X represents a carbon or nitrogen atom in the aromatic ring, Y represents an oxygen or sulfur atom, a further group Q, one or more groups Qi (Qi is one or several of the aforementioned groups Which may be attached to any unsaturated component of the ring) is —OH, —COOH, —N (CH 3 ) 2 , —N (CH 2 —CH 3 ) 2 , —CO—CH 3. , —CO—O—CH 3 , —O—CH 3 , —S—CH 3 , —SO 2 —CH 3 , —CN, —NO 2 or a halogen element, and R 5 is a group represented by the formula (IV ) And its metal and ammonium salts, n is 0 to 5 or oxygen or phosphorus is partially or completely replaced by nitrogen, sulfur, methylene groups or derivatives thereof. The present invention also relates to the use of the above compounds in the medical field, as well as methods for their preparation. |