| abstract |
Exposing the cell of cold-blooded vertebrate oocytes, ovum, ovary or early embryo or a cell extract thereof to the differentiated cell, or the nucleus of the differentiated cell, wherein the cold-blooded vertebrate has the following properties: (i Laterally protruding ribs and / or spinous processes; (ii) germ cells that do not contain germ cytoplasm; and / or (iii) the oocyte, egg, ovary, or early embryonic cell from which the cell extract is derived. A method of producing a reprogrammed cell or reprogrammed cell nucleus having one or more of expressing a highly conserved form of Oct-4 and / or nanog. In addition, the use of reprogrammed cells is provided. |