| abstract |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, as well as methods for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, their therapeutic use. Table method, and a pharmaceutical composition containing the same, wherein, R 1 is a R 5 O-group representing C 3-7 alkyl group R 5 is substituted by one or more fluoro for Or R 5 represents a C 3-7 alkylsulfonyl group optionally substituted by one or more fluoro; R 2 represents a C 1-4 alkyl group, hydroxy, fluoro, chloro or cyano wherein the represents,, n> 1 when it, each R 2 is independently selected; R 3 is, a) one or more of: hydroxy, fluoro, amino, mono- or di-C -3 alkylamino, carboxy or C 1-4 alkoxycarbonyl group by a cyclohexyl substituted optionally, b) one or piperidino substituted by more hydroxy it, c) represents the unsubstituted piperidino, But the following: R 4 represents cyano, R 1 represents 3-fluoropropylsulfonyloxy, or R 1 represents 3,3,3-trifluoropropoxy, or R 1 represents 3- Represents fluoropropoxy, or only when one of R 2 is methyl, d) one or more of the following: substituted by hydroxy, halo or C 1-4 alkyl groups Table phenyl, pyridyl substituted by e) C 1-4 alkyl group, or f) C 4-9 alkyl groups that are ; R 4 represents cyano or methyl; and n is 1, 2 or 3. |