| abstract |
Thieno [2,3-c] pyrazole derivatives of formula (I) Wherein A is an aryl or heteroaryl ring, the substituent —NHZR 5 on the ring is ortho to the CONH linker, and R 1 and R 2 are the same or different; Independently of each other, represents a hydrogen atom or an organic group, R 4 is a hydrogen or halogen atom or an organic group, Z is a direct bond,> C═O or —C (═O) NH—, R 5 is hydrogen or an organic group.), Or isomers, tautomers, carriers, metabolites, prodrugs and pharmaceutically acceptable salts thereof are provided. Methods for preparing them and pharmaceutical compositions containing them are also disclosed. The compounds of the present invention may be useful in the treatment and therapy of diseases associated with dysregulation of protein kinase activity such as cancer. |