| abstract |
Animal models for HCV replication and / or production of viruses or virus-like particles are provided. The present invention uses HCV replicons present in cells to deliver HCV nucleic acids in animal models, including animals that are immunocompromised, and to replicate and express HCV proteins. The invention further provides a method of treating or preventing HCV in a mammal, comprising administering to the mammal a combination comprising an immunomodulatory compound and another antiviral agent. Also provided are cell lines that exhibit reduced sensitivity to interferon alpha or any other immunomodulator, and methods of making or isolating such cell lines. |