abstract |
Heterocycle such as a benzimidazole carboxylic acid core structure having the formula Ia-1 wherein Z, X 1 , X 2 , X 5 , R 2 and R 10 are as defined herein Methods of synthesizing compounds and synthetic intermediates thereof are provided. The compound of formula Ia-1 and this synthetic intermediate can be used to prepare heterocyclic derivatives such as benzimidazole derivatives. |